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Brazilian Journal of Clinical Medicine and Review

Health Review

Vol. 2 No. 3 (2024): July/September - 2024

Differential roles of M1 and M2 microglia in Parkinson’s disease: a critical narrative review

DOI
https://doi.org/10.52600/2965-0968.bjcmr.2024.2.3.39-43
Submitted
December 14, 2023
Published
2024-01-31

Abstract

Parkinson's disease (PD) is marked by the selective loss of dopaminergic neurons, leading to debilitating motor and non-motor symptoms. Central to PD pathogenesis is the intricate involvement of microglia, the resident immune cells of the brain. This narrative review delves into the distinct functions of M1 and M2 microglia in the context of PD. M1 microglia exhibit pro-inflammatory characteristics, releasing cytotoxic factors that exacerbate neuronal damage. In contrast, M2 microglia contribute to neuroprotection by secreting anti-inflammatory cytokines and participating in the clearance of cellular debris. The dynamic interplay between these microglial phenotypes is explored, providing insights into their roles in disease progression. Emerging therapeutic strategies aimed at modulating microglial polarization are discussed, emphasizing their potential in PD intervention. By unraveling the nuanced contributions of M1 and M2 microglia in PD, this review not only advances our understanding of neuroinflammatory mechanisms but also underscores the importance of targeted interventions to alleviate disease-associated pathology and preserve neuronal integrity in Parkinson's disease.

References

  1. Pajares M, I Rojo A, Manda G, Boscá L, Cuadrado A. Inflamação na Doença de Parkinson: Mecanismos e Implicações Terapêuticas. Células. 2020 Jul 14;9(7):1687. doi: 10.3390/cells9071687.
  2. Liu TW, Chen CM, Chang KH. Biomarcador da Neuroinflamação na Doença de Parkinson. Int J Mol Sci. 2022 Abr 8;23(8):4148. doi: 10.3390/ijms23084148.
  3. Badanjak K, Fixemer S, Smajić S, Skupin A, Grünewald A. A Contribuição da Microglia para a Neuroinflamação na Doença de Parkinson. Int J Mol Sci. 2021 28 de abril;22(9):4676. doi: 10.3390/ijms22094676.
  4. Guo S, Wang H, Yin Y. Polarização da Microglia de M1 a M2 em Doenças Neurodegenerativas. Neurosci De Envelhecimento Frontal. 2022 16 de fevereiro;14:815347. doi: 10.3389/fnagi.2022.815347.
  5. Takahashi S, Mashima K. Neuroprotection and Disease Modification by Astrocytes and Microglia in Parkinson Disease. Antioxidants (Basel). 2022 Jan 17;11(1):170. doi: 10.3390/antiox11010170.
  6. Li J, Liu H, Wang X, Xia Y, Huang J, Wang T, Lin Z, Xiong N. A melatonina melhora a doença de Parkinson regulando a polarização da microglia em uma via dependente de RORα. NPJ Parkinsons Dis. 2022 Jul 8;8(1):90. doi: 10.1038/s41531-022-00352-5.
  7. Ciesielska A, Matyjek M, Kwiatkowska K. TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling. Cell Mol Life Sci. 2021 Feb;78(4):1233-1261. doi: 10.1007/s00018-020-03656-y.
  8. Yang C, Wang W, Deng P, Li C, Zhao L, Gao H. Fibroblast Growth Factor 21 Modulates Microglial Polarization That Attenuates Neurodegeneration in Mice and Cellular Models of Parkinson's Disease. Front Aging Neurosci. 2021 Dec 22;13:778527. doi: 10.3389/fnagi.2021.778527.
  9. Li B, Wang M, Chen S, Li M, Zeng J, Wu S, Tu Y, Li Y, Zhang R, Huang F, Tong X. A Baicalin Mitiga a Neuroinflamação através das Vias TLR4/MyD88/NF-κB e MAPK na Microglia BV-2 Estimulada por LPS. Biomed Res Int. 2022 Nov 9;2022:3263446. doi: 10.1155/2022/3263446.
  10. Li N, Stewart T, Sheng L, Shi M, Cilento EM, Wu Y, Hong JS, Zhang J. Imunoregulação da polarização microglial: uma função fisiológica não reconhecida da α-sinuclein. J Neuroinflamação. 2020 Sep 17;17(1):272. doi: 10.1186/s12974-020-01940-z.
  11. Wang Q, Luo Y, Ray Chaudhuri K, Reynolds R, Tan EK, Pettersson S. O papel da disbiose intestinal na doença de Parkinson: insights mecanicistas e opções terapêuticas. Cérebro. 2021 Out 22;144(9):2571-2593. doi: 10.1093/brain/awab156.
  12. Socała K, Doboszewska U, Szopa A, Serefko A, Włodarczyk M, Zielińska A, Poleszak E, Fichna J, Wlaź P. The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders. Pharmacol Res. 2021 Oct;172:105840. doi: 10.1016/j.phrs.2021.105840.
  13. Li Y, Chen Y, Jiang L, Zhang J, Tong X, Chen D, Le W. Inflamação Intestinal e Doença de Parkinson. Envelhecimento Dis. 2021 Dec 1;12(8):2052-2068. doi: 10.14336/AD.2021.0418. PMID: 34881085; PMCID: PMC8612622.
  14. Hamamah S, Aghazarian A, Nazaryan A, Hajnal A, Covasa M. Role of Microbiota-Gut-Brain Axis in Regulating Dopaminergic Signaling.
  15. Hirayama M, Ohno K. Parkinson's Disease and Gut Microbiota. Ann Nutr Metab. 2021;77 Suppl 2:28-35. doi: 10.1159/000518147.
  16. Klann EM, Dissanayake U, Gurrala A, Farrer M, Shukla AW, Ramirez-Zamora A, Mai V, Vedam-Mai V. O Eixo Intestino-Brain e Sua Relação com a Doença de Parkinson: Uma Revisão. Neurociência de Envelhecimento Frontal. 2022 Jan 7;13:782082. doi: 10.3389/fnagi.2021.782082.
  17. Generoso JS, Giridharan VV, Lee J, Macedo D, Barichello T. The role of the microbiota-gut-brain axis in neuropsychiatric disorders. Braz J Psychiatry. 2021 May-Jun;43(3):293-305. doi: 10.1590/1516-4446-2020-0987.
  18. Qiu X, Wang Q, Hou L, Zhang C, Wang Q, Zhao X. Inhibition of NLRP3 inflammasome by glibenclamide attenuated dopaminergic neurodegeneration and motor deficits in paraquat and maneb-induced mouse Parkinson's disease model. Toxicol Lett. 2021 Oct 1;349:1-11. doi: 10.1016/j.toxlet.2021.05.008.
  19. Yang HM, Wang YL, Liu CY, Zhou YT, Zhang XF. A time-course study of microglial activation and dopaminergic neuron loss in the substantia nigra of mice with paraquat-induced Parkinson's disease. Food Chem Toxicol. 2022 Jun;164:113018. doi: 10.1016/j.fct.2022.113018.

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