This cover image is based on the Health Review entitled The role of medial prefrontal cortex in cognition, aging and Parkinson disease by Dra. Lia de Oliveira Jereissati and colleagues. In this article the authors examines how aging affects cognitive activities regulated by the mPFC, a pivotal region for critical cognitive functions. By applying predetermined criteria, the review selects the most relevant articles to provide a comprehensive understanding of cognitive deficits mediated by the mPFC in both healthy and pathological aging.