This cover page represents the article titled "The Role of Medical Research in Advancing Knowledge in Health: where are we?" which explores the importance of medical research in expanding knowledge and improving patient outcomes. The article also emphasizes the impact of scientific discoveries on medical treatments, including advances in genomics, immunology, and biotechnology. Additionally, it discusses the need for continuous funding and collaboration in research, as well as the challenges and benefits of international collaboration, especially in low- and middle-income countries. Finally, the article reiterates the commitment of the Brazilian Journal of Clinical Medicine and Review to supporting and disseminating innovative research. It concludes that the future of healthcare depends on our commitment to research, which can improve patient outcomes and quality of life worldwide.