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Health Review

Vol. 3 No. 1 (2025): January/December - 2025

Clinical and laboratory profile of HELLP Syndrome: Integrative Literature Review

DOI
https://doi.org/10.52600/2965-0968.bjcmr.2025.3.1.bjcmr18
Submitted
September 13, 2024
Published
2024-10-10

Abstract

The objective of this study is to gather information that corroborates the main clinical and laboratory findings involving Hellp Syndrome, its repercussions and consequences during pregnancy. An Integrative review was carried out in August 2024, using the digital library Scientific Electronic Library Online (SciELO), the Virtual Health Library (VHL) and PUBMED in the databases using the Boolean operators: AND and OR. The results were obtained through management with the Rayyan 16 QCRI application and were structured in PRISMA flowcharts. With the search in the databases, 219 articles were found, of which 122 were selected for reading and, according to the objective of the present work, 10 articles were included in the research. In the studies observed, it is concluded that among the main hypertensive syndromes in pregnancy, HELLP syndrome is a specific clinical and laboratory entity, requiring early diagnosis, precisely because of the repercussions at the maternal-fetal level, as it increases complications such as the syndrome from respiratory distress, infections and long-term developmental problems.

References

  1. Santos Couto PL, Leal De Souza C, Tosoli Gomes AM, De Oliveira Silva D, Correia Marques S, Alves Vilela AB. Mortalidade materna por síndrome HELLP: interferência do perfil, condições clínicas e ginecológicas durante a gravidez. Cienc Enferm. 2022;28:28. Epub 2022 Dec 16. doi: 10.29393/ce28-28mmpa60028.
  2. Arigita Lastra M, Martínez Fernández GS. Síndrome HELLP: controversias y pronóstico [HELLP syndrome: controversies and prognosis]. Hipertens Riesgo Vasc. 2020 Oct-Dec;37(4):147-151. Spanish. doi: 10.1016/j.hipert.2020.07.002. Epub 2020 Aug 16. PMID: 32811776; PMCID: PMC7428701.
  3. Behrens M. Transformative education. Portuguese Education Magazine. 2020.
  4. Mendes KS, et al. Use of the bibliographic reference manager in the selection of primary studies in integrative reviews. Texto Contexto Enferm. 2019;28(4):1-3.
  5. dunvbun WO, Johnson BC, Urey DG. Hypertensive disorders in pregnancy at the John F. Kennedy Maternity Center (JFKMC), Liberia: burden, sub-types, and maternofetal outcome. Ethiop J Health Sci. 2023 Jul;33(4):601-610. doi: 10.4314/ejhs.v33i4.6. PMID: 38784217; PMCID: PMC11111178.
  6. Gomez-Aviles P, Gei AF, Martinez-Dominguez P. Caring for patients with gestational hypertensive disorders: essential takeaways. Methodist Debakey Cardiovasc J. 2024 Mar 14;20(2):120-123. doi: 10.14797/mdcvj.1311. PMID: 38495653; PMCID: PMC10941693.
  7. Guida JPS, Andrade BG, Pissinatti LGF, Rodrigues BF, Hartman CA, Costa ML. Prevalence of preeclampsia in Brazil: an integrative review. Rev Bras Ginecol Obstet. 2022 Jul;44(7):686-691. doi: 10.1055/s-0042-1742680. Epub 2022 Feb 9. PMID: 35139578; PMCID: PMC9948112.
  8. Dubey S, Rani J. Hepatic rupture in preeclampsia and HELLP syndrome: a catastrophic presentation. Taiwan J Obstet Gynecol. 2020 Sep;59(5):643-651. doi: 10.1016/j.tjog.2020.07.003. PMID: 32917311.
  9. Arduini PS, de Resende CV, da Silva JA, Ruiz MT. Nursing care for women with HELLP syndrome: a scoping review. Rev Esc Enferm USP. 2024;58. doi: 10.1590/1980-220x-reeusp-2024-0116en.
  10. Gilboa I, Gabbai D, Yogev Y, Dominsky O, Berger Y, Kupferminc M, et al. A prediction model for hemolysis, elevated liver enzymes, and low platelets syndrome in pre-eclampsia with severe features. Int J Gynaecol Obstet. 2024. doi: 10.1002/ijgo.15848.
  11. Gardikioti A, Venou TM, Gavriilaki E, Vetsiou E, Mavrikou I, Dinas K, Daniilidis A, Vlachaki E. Molecular advances in preeclampsia and HELLP syndrome. Int J Mol Sci. 2022 Mar 31;23(7):3851. doi: 10.3390/ijms23073851. PMID: 35409211; PMCID: PMC8999044.
  12. Monteiro-Brás I, Reynolds A, Guedes-Martins L, Silva P. Orientação clínica das doenças hipertensivas da gravidez. Acta Obstet Ginecol Port. 2022;16(3):213-233.
  13. Santos Couto PL, Leal De Souza C, Tosoli Gomes AM, De Oliveira Silva D, Correia Marques S, Alves Vilela AB. Mortalidade materna por síndrome HELLP: interferência do perfil, condições clínicas e ginecológicas durante a gravidez. Cienc Enferm. 2022;28. doi: 10.29393/ce28-28mmpa60028.

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